Images on the website are created in Cinema4D, BioBlender and Maya by Alex Goryaynov.
Alex Goryaynov, PhD.
Senior Scientist (Nanotechnology and Bionengineering) at Quantum-Si
Currently I am working on world’s first next generation protein sequencing device to accelerate the study of diseases and pandemics.
The Quantum-Si ecosystem encompasses everything required to decode the molecules of life, including sample preparation, sequencing, and data analysis. The transition from analog to digital proteomics enables a new generation of more sensitive and accurate research tools and diagnostics.Over the past fifteen years, next-generation DNA sequencing has transformed every aspect of the life sciences. However, genetics is only one component of human disease. New tools are required to understand how genes interact with the environment to improve how we develop drugs, diagnose patients, and combat outbreaks. Protein-based approaches have always held tremendous promise, but despite massive improvements in DNA sequencing technology, proteomics (the study of proteins on a large scale) has not advanced as rapidly.
Postdoctoral Scientist at Yale School of Medicine. Biophysics, Cell Biology and Super-resolution Microscopy (2014-2016).
I am working on applying novel super-resolution microscopy techniques to various biological systems in Eukaryotic cells in Bewersdorf lab at yale school of medicine. Primarily I am involved in the study of the golgi complex, protein trafficking, protein structure, phototoxicity, developing of image analysis techniques and improving and developing of the microscopy setups. I am also an aspiring scientific illustrator and enjoy creating scientific 3D models.
Organelles and their function studied by STED
Mitochondria structure shown with sted
Single molecule switching nanoscopy
The concept of single molecule switching nanoscopy. (a) The Airy disk point
spread function of optical microscopy. The image is displayed using a nonlinear intensity scale. (b) The Rayleigh criterion is defined in terms of the distance at which the principal maximum of one Airy disk coincides with the first minimum of the second Airy disk. (c) Two emitters cannot be resolved, when the distance is smaller than the Rayleigh criterion. (d) The imaging and analysis process of single molecule localization microscopy.
Nanoscopy
LEica sted microscope in our lab
3D super-resolution imaging of ER
Image by Yongdeng Zhang
Super-resolution image of microtubules in a 53 × 53–μm2 ROI imaged at 400 f.p.s. in 40 s. The data set was processed by our new sCMOS-specific algorithm, resulting in about 4.4 million position estimates after filtering. Image by Fang huang.